Fri Mar 08 2024

136 articles - From Friday Mar 01 2024 to Friday Mar 08 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Aliment Pharmacol Ther

Applying Lyon consensus criteria in the work-up of patients with extra-oesophageal symptoms - A multicentre retrospective study.

This study underscores the limited diagnostic accuracy of laryngoscopy, emphasising the necessity of impedance-pH monitoring for confirming GERD diagnoses using Lyon 2.0 criteria in patients with suspected extra-oesophageal symptoms.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Degree of Discordance Between FIB-4 and Transient Elastography: An Application of Current Guidelines on General Population Cohort.

Using FIB-4 in the AGA/AASLD guidelines to risk-stratify subjects at risk for MASLD-associated fibrosis results in many subjects being misclassified into the low and high-risk categories. Therefore, it may be worthwhile considering caution in interpretation and/or alternative strategies.

Pubmed   Journal   ReadQx 

White Paper: American Gastroenterological Association Position Statement: The Future of IBD Care in the United States - Removing Barriers and Embracing Opportunities.

However, there are opportunities to improve access to high quality, patient centered care. This position statement outlines the policy and advocacy goals that the AGA will prioritize for collaborative efforts with patients, providers, and payors.

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Gastroenterology

AGA Clinical Practice Update on Diagnosis and Management of Cannabinoid Hyperemesis Syndrome: Commentary.

Methods This CPU was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology. This expert commentary incorporates important as well as recently published studies in this field, and it reflects the experiences of the authors.

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Hepatology

Metabolic dysfunction-associated steatotic liver disease: Update and impact of new nomenclature on the American Association for the Study of Liver Diseases practice guidance on nonalcoholic fatty liver disease.

The guidance document is relevant and can be utilized for the diagnosis, risk stratification, and management of patients with MASLD. This commentary serves as an accompanying article to the NAFLD Practice Guidance and helps it clinical application in the light of the new nomenclature.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic review: Defining, diagnosing and monitoring small bowel strictures in Crohn's disease on intestinal ultrasound.

This systematic review is the first step for a structured program to develop a stricture IUS index for CD.

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Am J Gastroenterol

Adenomas and Sessile Serrated Lesions in 45-49- Year-Old Individuals Undergoing Colonoscopy: A Systematic Review and Meta-Analysis.

Pubmed   Journal   ReadQx 

EUS-Guided Vs. ERCP-Guided Biliary Drainage as Primary Approach to Malignant Distal Biliary Obstruction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

EUS-BD is an efficient and safe alternative to ERCP in MDBO. An almost nonexistent risk of procedure-related pancreatitis, lower procedure time, and ease of use makes this an attractive primary approach to biliary decompression in centers with expertise.

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Clin Gastroenterol Hepatol

Antibiotic exposure and risk of new-onset inflammatory bowel disease: a systematic review and dose-response meta-analysis.

Antibiotic exposure was significantly associated with an increased risk of new-onset IBD, and a positive nonlinear dose-response relationship was observed. Antibiotic stewardship may be important for reducing IBD risk.

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GLOBAL PREVALENCE OF PANCREATIC CYSTIC LESIONS IN THE GENERAL POPULATION ON MAGNETIC RESONANCE IMAGING: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Subgroup analysis showed higher PCL prevalence when imaging findings were confirmed by independent radiologist(s) (25%; 95%CI 16-33) than when chart review alone was used (5%; 95%CI 4-7; p<0.01). There was no independent association of PCL prevalence with geographic location (Europe, North America or Asia), MRI indication (screening vs evaluation of non-pancreatic pathology), enrollment period, sample size, magnet strength (1.5 vs 3 tesla), and MRI sequence (MRCP vs no MRCP) CONCLUSION: In this systematic review, the global prevalence of PCLs using a highly sensitive non-invasive imaging modality ranged between 13% to 18%.

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Prevalence of Gastric Precursor Lesions in Countries with Differential Gastric Cancer Burden: A Systematic Review & Meta-Analysis.

Gastric precursor lesions have differences in prevalence in regions with differential GC incidence and are associated with H.pylori infection. Given the substantial prevalence of precursor lesions in both symptomatic and asymptomatic individuals, symptomatic evaluation may not be sufficient to identify individuals at risk. These estimates provide important insights for tailoring GC prevention strategies.

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Gastrointest Endosc

Disparities in race, ethnicity, sex, and age inclusion in pancreatic cancer screening studies: A systematic review and meta-analysis.

Substantial disparities in race, ethnicity, sex, and age reporting and inclusion in pancreatic cancer studies were noted, even among high-quality and publicly funded studies.

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Hepatology

Fiber and whole grain intakes in relation to liver cancer risk: An analysis in two prospective cohorts and systematic review and meta-analysis of prospective studies.

Dietary fiber and whole grains were inversely associated with liver cancer risk. Further research exploring potential mechanisms and different fiber types is needed.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

CAMP-B score predicts the risk of hepatocellular carcinoma in patients with chronic hepatitis B after HBsAg seroclearance.

The CAMP-B score (cirrhosis, age ≥50 years, male sex and platelet count <150,000/mm 3 /L) was significantly associated with HCC development after HBsAg seroclearance. CAMP-B score can be easily implemented in real-world clinical practice and helps stratify HCC risk in patients with CHB following HBsAg seroclearance.

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Development and validation of a brain fog scale for coeliac disease.

The brain fog assessment and severity scale is the first patient-informed clinical outcomes assessment tool measuring brain fog in coeliac disease. It is brief and validated for two time-based formats. Further research coupling it with biomarker discovery is needed to confirm its validity as a predictor of cognitive performance.

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Effectiveness and safety of a third-line rescue treatment for acute severe ulcerative colitis refractory to infliximab or ciclosporin (REASUC study).

Third-line rescue treatment avoided colectomy in over half of the patients with ASUC and may be considered a therapeutic strategy.

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Impact of inflammatory bowel disease on the risk of acute coronary syndrome: A Swedish Nationwide Cohort Study.

In this contemporary cohort of patients with IBD, exposed to modern IBD care, there was an increased risk for ACS compared with individuals from the general population.

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Inflammatory bowel disease (IBD) patients with impaired quality of life on biologic therapy benefit from the support of an IBD nurse specialist: Results of a randomised controlled trial in Germany (IBDBIO-ASSIST study).

High baseline satisfaction of IBD patients with treatment and the relatively high baseline sIBDQ values may have contributed to the lack of significant difference in sIBDQ scores for the overall sample. However, patients with impaired QoL derived significant benefit from additional care provided by an IBD nurse specialist, leading to meaningful improvements in sIBDQ over the long term.

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Review article: Pathogenesis of MASLD and MASH - role of insulin resistance and lipotoxicity.

Targeting tissue-specific insulin resistance and hyperinsulinaemia while decreasing FFA load (lipotoxicity) through dietary and lifestyle changes remain the best upstream interventions.

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Am J Gastroenterol

High Body Mass Index and Response to Anti-TNF Therapy in Pediatric Crohn Disease.

Overweight and obese patients with PCD are more likely to experience adalimumab treatment failure than those with normal BMI. Higher BMI was associated with lower drug trough levels. Standard adalimumab dosing may be insufficient for overweight children with PCD. Among infliximab initiators, there was no observed difference in clinical outcomes or drug levels, perhaps due to weight-based dosing and/or greater use of proactive drug monitoring.

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Clin Gastroenterol Hepatol

Defining Endoscopic Remission in Crohn's Disease: MM-SES-CD and SES-CD Thresholds Associated with Low Risk of Disease Progression.

Achievement of MM-SES-CD <22.5 or SES-CD <4 in patients with ileocolonic or colonic CD is associated with low risk of disease progression and may be suitable targets in clinical trials and practice for endoscopic healing.

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Dynamic prediction of advanced colorectal neoplasia in inflammatory bowel disease.

The new prediction model showed good discrimination and calibration, however, generalizability results varied. Future research should focus on formal external validation and relate predicted aCRN risks to surveillance intervals prior to clinical application.

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Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study.

The tolerability profile of efruxifermin added to GLP-1RA appeared comparable to that of either drug alone, while also significantly reducing HFF and noninvasive markers of fibrosis in patients with MASH and T2D. Liver health in patients already on a GLP-1RA may be further improved by addition of efruxifermin. no. NCT05039450.

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The Efficacy of Real-Time Computer-Aided Detection of Colonic Neoplasia In Community Practice: A Pragmatic Randomized Controlled Trial.

In a single-center pragmatic randomized controlled trial, real-time CADe modestly improved ADR and APC in average-detector community endoscopists. (ClinicalTrials.gov number, NCT05963724).

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Endosc Int Open

Assessment of pancreatic ductal stone density on non-contrast computed tomography for predicting the outcome of extracorporeal shock wave lithotripsy.

The SD is a significant predictor of ESWL success followed by ductal clearance at ERCP, and <1106.5 HU is a predictor of good candidates for ESWL therapy.

Pubmed   Journal   ReadQx   PMC

Association of short-course antimicrobial therapy and bacterial resistance in acute cholangitis: Retrospective cohort study.

In acute cholangitis, the administration of antimicrobials within 3 days of ERCP may suppress the development of resistant bacteria.

Pubmed   Journal   ReadQx   PMC

Comparison of diagnostic outcomes, safety, and cost of Franseen-tip 19G versus 22G needles for endoscopic ultrasound-guided liver biopsies.

The Franseen-tip 19G outperforms 22G with a significantly lower fragmentation rate, longer AL, LIC, and a higher number of CPT with a marginal increase in the procedure cost, without any difference in diagnostic yield and safety.

Pubmed   Journal   ReadQx   PMC

Evaluation of exclusive internal endoscopic drainage for complex biloma with transluminal and transpapillary stenting.

If both techniques can be performed, EUS-TBD should be considered because of the short times for the procedure, hospital stay. and biloma resolution.

Pubmed   Journal   ReadQx   PMC

Interactive training with a novel simulation model for upper gastrointestinal endoscopic hemostasis improves trainee technique and confidence.

Our study demonstrates the potential of our simulation-based training model as a valuable tool for improving technical skills and confidence in trainees learning to perform endoscopic hemostasis.

Pubmed   Journal   ReadQx   PMC

Safety and efficacy of early versus late removal of LAMS for pancreatic fluid collections.

Early LAMS removal (< 4 weeks) did not prevent AEs but did lead to increased clinical failure.

Pubmed   Journal   ReadQx   PMC

Same-session endoscopic diagnosis and symptom palliation in pancreato-biliary malignancies: Clinical impact of rapid on-site evaluation (ROSE).

g. uncovered SEMS or therapeutic EUS), potentially reducing hospitalization and time to oncological treatments.

Pubmed   Journal   ReadQx   PMC

The Bethesda ERCP Skills Assessment Tool (BESAT) can reliably differentiate endoscopists of different experience levels.

Study findings demonstrate that the BESAT, a video-based ERCP skill assessment tool, has high inter-rater reliability and has discriminative validity in differentiating novice from expert ERCP skill. Further investigations are needed to determine the role of video-based assessment in improving trainee learning curves and patient outcomes.

Pubmed   Journal   ReadQx   PMC

The professional background of a referring physician predicts the diagnostic yield of small bowel capsule endoscopy in suspected small bowel bleeding.

The professional background of referring physicians significantly improves the diagnostic yield of SBCE and contributes to controlling public health costs.

Pubmed   Journal   ReadQx   PMC

Endoscopy

A simplified algorithm to evaluate the risk of submucosal invasive cancer in large (>/=20mm) non-pedunculated colonic polyps.

This decision-making algorithm simplifies identification of LNPCPs with an increased risk of potential SMIC. When combined with surface optical evaluation, it facilitates accurate lesion characterisation and resection choices.

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Efficacy and safety of endoscopic ultrasound-guided hepatico-gastrostomy: a meta-regression analysis.

EUS-HGS represents an effective and safe procedure for EUS-guided biliary drainage in patients with malignant biliary obstruction. Future studies should address the impact of center experience, patient selection, and use of dedicated stents to improve this technique's performance.

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Gastroenterology

Impact of Longitudinal Alcohol Use Patterns on Long-Term Risk of Cirrhosis Among U.S. Veterans with Steatotic Liver Disease.

One in nine Veterans with steatotic liver disease report concurrent high-risk alcohol use, which is associated with 43% greater risk of cirrhosis compared to no alcohol use. However, reducing alcohol use lowers risk of cirrhosis, emphasizing the importance of timely alcohol use assessment and early interventions to address high-risk alcohol use in steatotic liver disease.

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Incidence and prediction of unrelated mortality after successful endoscopic eradication therapy for Barrett's neoplasia.

The other-cause mortality risk after successful EET was more than 40 times higher [48; 95% CI 15-99] than the risk of EAC-related mortality. Our findings reveal that younger post-EET patients exhibit a significantly reduced life expectancy when compared to the general population. Furthermore, they emphasize the strong predictive ability of CCI for long-term mortality after EET. This straightforward scoring system can inform decisions regarding personalized FU, including appropriate cessation timing. (NL7039).

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Sacral neural crest-independent origin of the enteric nervous system in mouse.

sNCCs do not contribute to the murine ENS, suggesting that the mammalian ENS exclusively originates from vNCCs. These results have immediate implications for comprehending (and devising treatments for) congenital ENS disorders, including Hirschsprung's disease.

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TGF-β1 Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis through Transcriptionally Upregulating PD-L1 and CXCL12.

SOX18 promoted the accumulation of immunosuppressive TAMs and Tregs in microenvironment by transactivating CXCL12 and PD-L1. CXCR4 inhibitor or TGFβR1 inhibitor in synergy with anti-PD-L1 represented a promising combination strategy to suppress HCC progression and metastasis.

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Tertiary Lymphoid Structure-Associated B Cells Enhance CXCL13+CD103+CD8+ Tissue-Resident Memory T-Cell Response to Programmed Cell Death Protein 1 Blockade in Cancer Immunotherapy.

This study further reveals a crucial role for cellular communication between TLS-associated B cell and CXCL13 + CD103 + CD8 + Trm cells in antitumor immunity, providing valuable insights into the potential use of the lymphotoxin-α/TNFR2 axis within CXCL13 + CD103 + CD8 + Trm cells for advancing immunotherapy strategies in GC.

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Gastrointest Endosc

An Endoscopic Scoring System for Achalasia: The CARS score.

We developed a CARS score based on reliability performance in a video-based survey and tested the score in clinical setting. The CARS score performed well in predicting achalasia.

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Diagnostic Performance of Endoscopic Ultrasound Elastography for Differential Diagnosis of Gallbladder Polyp.

EUS-EG and SR values can be used as a supplementary method for evaluating GB polyps.

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Endoscopic Ultrasound Guided Liver Palpation As a Screening Tool for Advanced Fibrosis and Cirrhosis in Patients with Suspected Metabolic Dysfunction-Associated Steatotic Liver Disease: A Pilot Study.

EUS liver palpation is a novel, accurate, and easy-to-use screening tool for advanced fibrosis and cirrhosis in patients with MASLD.

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Establishment of a patient-specific avatar organoid model derived from endoscopic ultrasonography-guided fine needle biopsy for timely clinical application in pancreatic ductal adenocarcinoma.

This PDAC PDO platform allows several therapeutic drugs to be tested within a short time window and opens the possibility for timely personalized medicine as a "Patient Avatar Model" in clinical practice.

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Long-term outcomes of endoscopic resection for well-differentiated nonampullary duodenal neuroendocrine tumors.

Endoscopic resection is safe and effective and provides a favorable long-term outcome for patients with well-differentiated NAD-NETs without regional lymph node or distant metastasis.

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Prospective multicenter trial of the cryoballoon ablation system for superficial esophageal squamous cell carcinoma on the post-endoscopic resection scar. A CRYO-SCAR study (EPOC1902).

CBAS is a potentially safe and effective approach for SESCC on post-ER scars and represents an encouraging alternative to traditional endoscopic treatments.

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Safety, Efficacy and Clinical Utility of the 5.1mm EndoRotor Powered Debridement Catheter for Treatment of Walled-Off Pancreatic Necrosis.

This is the first multi-center retrospective study to investigate the efficacy and safety of the 5.1 mm EndoRotor catheter for WON. Results from this study showed an average of 1.6 DEN sessions were needed to achieve WON resolution with an 85% single session reduction in solid debris and a 70% single session decrease in WON area with minimal adverse events.

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Gut

Absence of a pancreatic microbiome in intraductal papillary mucinous neoplasm.

The 'microbiome' of IPMNs and other pancreatic cystic neoplasms does not deviate from the background signature of negative controls, supporting the concept of a sterile environment. Outlier signals may appear in a small fraction of patients following recent invasive endoscopic procedures. No associations between microbial patterns and clinical or cyst parameters were apparent.

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Genetic and transcriptomic landscape of colonic diverticulosis.

Our results suggest that tissue remodelling is a primary mechanism for diverticula formation. Individuals with an increased genetic proclivity to diverticulitis exhibit a larger numbers of diverticula on colonoscopy.

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MASH Resolution Index: development and validation of a non-invasive score to detect histological resolution of MASH.

The MASH Resolution Index may be a useful score to non-invasively identify MASH resolution.

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Hepatology

Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis.

GzmB induces apoptosis and fibrosis in sclerosing cholangitis, whereas TRAIL regulates inflammatory and cytotoxic immune responses subsequently leading to reduced liver injury and fibrosis.

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Autoimmune diseases in primary sclerosing cholangitis and their first-degree relatives.

Individuals with PSC and their first-degree relatives had higher odds for autoimmune disease compared to matched comparators. This finding provides validation for prior genetic discoveries at a phenotypic level. Autoimmune comorbidity did not impact severe outcome.

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Chronic Hepatitis B baseline viral load and on-treatment liver cancer risk: A multinational cohort study of HBeAg-Positive patients.

In a multinational cohort of HBeAg-positive, non-cirrhotic, adult patients with CHB, baseline HBV viral load was significantly associated with HCC risk despite antiviral treatment. Patients with the highest viral load who initiated treatment had the lowest long-term risk of HCC development.

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Clinical outcomes and prognostic factors after HCV clearance with DAA in HIV/HCV coinfected patients with advanced Fibrosis/Cirrhosis.

NLNA events were the leading causes of morbidity and mortality after DAA cure among coinfected patients with AdF/cirrhosis. Among those with cACLD, baseline LSM and posttreatment LSM-based models helped to assess decompensation and HCC risk.

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Continuous home terlipressin infusion increases handgrip strength and reduces ascites - a prospective randomized cross-over study.

This novel study demonstrates a significant increase in handgrip strength, reduction in paracentesis volume and improved quality of life in patients with decompensated cirrhosis treated with continuous terlipressin infusion. These findings provide a strong rationale for the use of ambulatory CTI in appropriately selected patients with cirrhosis.

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Development of a liver disease-Specific large language model chat Interface using retrieval augmented generation.

In this demonstration, we built a disease-specific and PHI-compliant LLMs using RAG. While LiVersa demonstrated higher accuracy in answering questions related to hepatology - there were some deficiencies due to limitations set by the number of documents used for RAG. LiVersa will likely require further refinement before potential live deployment. The LiVersa prototype, however, is a proof of concept for utilizing RAG to customize LLMs for clinical use cases.

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Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort.

Serum MMP-7 has high discriminative properties to differentiate BA from other forms of neonatal cholestasis. MMP-7 cutoff values vary according to assay technology. Using MMP-7 in evaluation of cholestatic infants may simplify diagnostic algorithms and shorten time to hepatoportoenterostomy.

Pubmed   Journal   ReadQx 

Genotype correlates with clinical course and outcome of children with tight junction protein 2 (TJP2) deficiency-related cholestasis.

Patients with the TJP2-C genotype carrying PPTMs in both alleles had a rapidly progressive course, leading to early decompensation and death if they did not receive timely LT.

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Predictive factors for decompensating events in cirrhotic patients with primary biliary cholangitis under different lines of therapy.

Advanced PBC, rather than OCA and fibrates, was found to be associated with decompensating events. Therefore, biochemical and clinical variables should be considered when making decisions about the management of these drugs. Moreover, a positive response to OCA and fibrates reduced the risk of decompensation.

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Recurrent alcohol-associated hepatitis is common and is associated with increased mortality.

RAH is common and has a more aggressive clinical course, including increased mortality. Patients surviving an episode of AH should undergo intense alcohol use disorder therapy to prevent RAH.

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Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.

Restoring SRSF3 abundance in KCs offers a strategy against obesity-associated tissue inflammation and insulin resistance by preventing bacterial DNA accumulation.

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Reversing malnutrition and low muscle strength with targeted enteral feeding in patients awaiting liver transplant: A randomized controlled trial.

Targeted enteral feeding before LT improves HGS, anthropometry and immune function in severely malnourished cirrhotic patients. These findings provide a strong rationale for early consideration of NGF to reverse malnutrition and improve muscle strength. Appropriately powered studies should explore whether NGF can also impact clinically relevant outcomes including pre- and post-transplant mortality.

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Simple blood tests to diagnose compensated advanced chronic liver disease and stratify risk of clinically significant portal hypertension.

Simple, broadly available laboratory tests (FIB-4/VITRO) facilitate cACLD detection and CSPH risk stratification in patients with (suspected) liver disease. This blood-based approach is applicable outside of specialized clinics and may promote early intervention.

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Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis - a randomized controlled trial.

Tranexamic acid significantly reduces the failure to control bleeding by day 5 and failure to prevent rebleeding after day 5 till 6 weeks in patients with advanced liver cirrhosis (CTP class B or C) presenting with UGIB, by preventing bleeding from EVL site.

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J Hepatol

CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis.

Our study uncovered a previously unrecognized anti-apoptotic CD1d-JAK2-STAT3 axis in hepatocytes that conferred hepatoprotection and highlighted the potential of hepatocyte CD1d-directed therapy for liver injury and fibrosis in NASH, as well as in other liver diseases associated with hepatocyte apoptosis. Impact and implications Excessive and/or sustained hepatocyte apoptosis is critical in driving liver inflammation and injury. The mechanisms underlying the regulation of hepatocyte apoptosis in non-alcoholic steatohepatitis (NASH) remain largely unclear. Here, we found that CD1d expression in hepatocytes substantially decreases and negatively correlates with the severity of liver injury in patients with NASH. We further revealed a previously unrecognized anti-apoptotic CD1d-JAK2-STAT3 signaling axis in hepatocytes, which confers significant protection against liver injury in NASH and acute liver diseases. Thus, hepatocyte CD1d-targeted therapy could be a promising strategy to manipulate liver injury in both NASH and other hepatocyte apoptosis-related liver diseases.

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Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism.

SLC25A15 is hypoxia-responsive in HCC, and low SLC25A15 levels result in glutamine reprogramming through SLC1A5 and OGDHL regulation, promoting HCC progression and regulating cell sensitivity to anti-PD-L1. Interrupting the glutamine-derived energy supply is a potential therapeutic strategy for treating SLC25A15-deficient HCC. Impact and implications We first demonstrated the tumor suppressor role of solute carrier family 25 member 15 (SLC25A15) in hepatocellular carcinoma (HCC) and showed that its deficiency leads to reprogramming of glutamine metabolism to promote HCC development. SLC25A15 can serve as a potential biomarker to guide the development of precision therapeutic strategies aimed at targeting glutamine deprivation. Furthermore, we highlight that the use of an inhibitor of glutamine utilization can enhance the sensitivity of low SLC25A15 HCC to anti-PD-L1 therapy.

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Multidrug-resistant bacterial infections after liver transplantation: prevalence, impact, and risk factors.

MDR infections are highly prevalent after LT and have a significant impact on prognosis. E. faecium is the most frequently isolated MDR microorganism. New pharmacological and surveillance strategies aimed at preventing MDR infections after LT should be considered for patients with high-risk factors.

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PTEN Deficiency Induces an Extrahepatic Cholangitis-Cholangiocarcinoma Continuum via Aurora kinase A in Mice.

Pten deficiency in extrahepatic cholangiocytes and peribiliary glands led to a cholangitis-to-cholangiocarcinoma continuum through an Aurka-dependent manner. These findings offer new insights into preventive and therapeutic interventions for extrahepatic CCA. Impact and implications The aberrant PTEN-PI3K-AKT signaling pathway is commonly observed in human extrahepatic cholangiocarcinoma (eCCA), a disease with a poor prognosis. In our study, we developed a mouse model mimicking cholangitis to eCCA progression by conditionally deleting the Pten gene via Pdx1-Cre in epithelial cells and peribiliary glands of the extrahepatic biliary duct. The conditional Pten deletion in these cells led to cholangitis, which gradually advanced to dysplasia, ultimately resulting in eCCA. The loss of Pten heightened Akt signaling, cell proliferation, inflammation, fibrosis, DNA damage, epigenetic signaling, epithelial-mesenchymal transition (EMT), cell dysplasia, and cellular senescence. Genetic deletion or pharmacological inhibition of Aurka successfully halted the disease progression. This model shall be valuable for testing novel therapies and unraveling the mechanisms of eCCA tumorigenesis.

Pubmed   Journal   ReadQx 

Single cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity.

Our study provides conceptually novel insights into the immuno-pathological control of HBV cure, and opens exciting new avenues for clinical management, biomarker discovery and therapeutic interventions. We believe that the discoveries from this study, as it relates to the activation of an innate and altered immune response that may facilitate sustained, low-grade inflammation, may have broader implications in the resolution of chronic viral hepatitis.

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Using liver stiffness to predict and monitor the risk of decompensation and mortality in patients with alcohol-related liver disease.

Liver stiffness by transient elastography predicts decompensation and all-cause mortality in patients with compensated alcohol-related liver disease both at diagnosis and when used for monitoring.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Gastroenterology

Diagnosis and Management of Pancreatic Cysts.

Pubmed   Journal   ReadQx 

Ferroptosis: Biology and Role in Gastrointestinal Disease.

While ferroptotic cell death is associated with dysfunction of the intestinal epithelium, the underlying molecular basis is poorly understood. As the mechanisms regulating ferroptosis become further elucidated, there is clear potential to utilize ferroptosis to achieve therapeutic benefit.

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Our New President-Maria T. Abreu, MD, AGAF.

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Gastrointest Endosc

Do's and Don'ts in Esophageal Peroral Endoscopic Myotomy: Troubleshooting, Managing Adverse Events and Tips for Success.

Pubmed   Journal   ReadQx 

J Hepatol

Multi-omics characterization of healthy and PSC human liver - what we know and what we learn.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

A Curious Cause of Corkscrew Esophagus.

Pubmed   Journal   ReadQx 

Accidental Hydrogen Peroxide Ingestion Causing Extensive Portal Venous Gas.

Pubmed   Journal   ReadQx 

Comment on: The Comparative Effectiveness of Ciprofloxacin and Metronidazole for an Initial Episode of Pouchitis: A Propensity-Matched Study.

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Esophageal liposarcoma of the oropharyngeal-esophageal junction.

Pubmed   Journal   ReadQx 

Gastric Hemangiopericytoma: An Unusual Presentation of Malignant Gastric Cancer. Case Report and Review of Literature.

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Clin Gastroenterol Hepatol

Assessing Diagnostic Performance of Modifications to the Rome IV Criteria for Irritable Bowel Syndrome.

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MALT lymphoma of the esophagus.

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PHOSPHATIDYLETHANOL DETECTS OCCULT HEAVY ALCOHOL USE IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS.

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Serum Ammonia Levels Do Not Correlate With Overt Hepatic Encephalopathy Severity in Hospitalized Patients With Cirrhosis.

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The Global Burden of Alcohol-associated Cirrhosis and Cancer in Young and Middle-aged Adults.

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The Management of Colorectal Neoplasia in Patients With Inflammatory Bowel Disease.

Pubmed   Journal   ReadQx 

Endosc Int Open

A stent-removing thread sticking adjacent to the duodenoscope elevator identified using the double-scope technique.

Pubmed   Journal   ReadQx   PMC

Emergency digital cholangioscopy-assisted electrohydraulic lithotripsy for basket impaction with an entrapped bile duct stone.

Pubmed   Journal   ReadQx   PMC

Endoscopy

A self-made three-arm clip for closure of a large wound after endoscopic full-thickness resection.

Pubmed   Journal   ReadQx   PMC

Advancing the Practice of Gastrointestinal Endoscopy Through Research.

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Band-on-band endoscopic variceal ligation: a technique for the treatment of esophageal varices in case of band misplacement.

Pubmed   Journal   ReadQx   PMC

Cold snaring biopsies to increase screening efficacy during endoscopic surveillance of patients at high risk of diffuse gastric cancer.

Pubmed   Journal   ReadQx   PMC

Endoscopic intermuscular dissection of an undetermined submucosal lesion with adaptive traction to obtain a free vertical margin.

Pubmed   Journal   ReadQx   PMC

Endoscopic resection of a huge tumor located at an anatomically challenging position using an innovative extra snare traction method.

Pubmed   Journal   ReadQx   PMC

Endoscopic submucosal dissection using ultrathin endoscope for early gastric cancer progressing from pyloric ring to bulb.

Pubmed   Journal   ReadQx   PMC

Endoscopy E-Videos - recently published.

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First report of gastric endoscopic intermuscular dissection.

Pubmed   Journal   ReadQx   PMC

Innovations for colonic endoscopic submucosal dissection: combination of the latest game changers.

Pubmed   Journal   ReadQx   PMC

Management of choledocholithiasis with an ultraslim cholangioscope in a patient with possible anaphylaxis to contrast medium.

Pubmed   Journal   ReadQx   PMC

Multiple ulcerated submucosal masses in the gastrointestinal tract: a rare presentation of metastatic cutaneous malignant melanoma.

Pubmed   Journal   ReadQx   PMC

No-touch endoscopic full-thickness resection using reopenable-clip over-the-line method for gastric gastrointestinal stromal tumor.

Pubmed   Journal   ReadQx   PMC

Precut over a pancreatic stent using the marking method to aid biliary cannulation in a patient with Roux-en-Y reconstruction.

Pubmed   Journal   ReadQx   PMC

Repeat endoscopic intermuscular dissection of the visible scar after noncurative endoscopic intermuscular dissection of a rectal neuroendocrine tumor.

Pubmed   Journal   ReadQx   PMC

Treatment of a sessile serrated adenoma/polyp deeply invading the appendiceal orifice enabled by combined adaptive traction and underwater endoscopic submucosal dissection.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

A colorful conundrum: dark urine in a patient with inflammatory bowel disease.

Pubmed   Journal   ReadQx 

Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on PRoBE Design.

Pubmed   Journal   ReadQx 

Prevalence of Sessile Serrated Lesions in Individuals with Positive Fecal Immunochemical Test Undergoing Colonoscopy: Results from a Large Nationwide Veterans Affairs Database.

Pubmed   Journal   ReadQx 

Single-Use vs. Reusable Duodenoscopes: How Infection Knowledge Gaps Are Driving Environmental Harm and What Can Be Done.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

ADENOMA-LIKE ADENOCARCINOMA.

Pubmed   Journal   ReadQx 

Ampullary neuroendocrine tumor: endoscopic papillectomy, an efficacy and safety treatment.

Pubmed   Journal   ReadQx 

Coil Migration Into the Pulmonary Artery After Gastric Variceal EUS Guided Coil Embolization.

Pubmed   Journal   ReadQx 

Combined Endoscopic Stricturotomy and Lumen Apposing Metal Stent in the Treatment of Crohn's Disease with Primary Ileocecal Valve Stricture.

Pubmed   Journal   ReadQx 

Diagnosis of Indeterminate Biliary Strictures: GIE Top Tips for Advanced Endoscopy.

Pubmed   Journal   ReadQx 

Endoscopic Removal of Gossypiboma: A Rare Cause of Gastric Outlet Obstruction.

Pubmed   Journal   ReadQx 

Top tips for performing high-quality optical zoom chromocolonoscopy.

Pubmed   Journal   ReadQx 

Unlooping the meandering main pancreatic duct in chronic pancreatitis.

Pubmed   Journal   ReadQx 

Gut

Recurrent intestinal ulcers and perforations complicated with pigmentation.

Pubmed   Journal   ReadQx 

Role of patient and staff mobility in scope 3 emissions in GI endoscopy.

Pubmed   Journal   ReadQx 

Hepatology

Duet of humoral and cellular immunity for conquering hepatitis C virus.

Pubmed   Journal   ReadQx 

Hepatitis C elimination: Tailoring the approach to each country's needs and realities.

Pubmed   Journal   ReadQx 

Letter to the Editor: How does bile acid-induced IRF3 phosphorylation mediate cholestatic liver and kidney injury? ---more need to be known.

Pubmed   Journal   ReadQx 

Letter to the Editor: Is right heart assessment vital for evaluating Terlipressin-related outcomes in Hepatorenal Syndrome-AKI?

Pubmed   Journal   ReadQx 

Letter to the Editor: Provider preparedness for functional cure of chronic hepatitis B.

Pubmed   Journal   ReadQx 

Letter to the Editor: Statins as potential confounding-factors to investigate the association between use of GLP-1 receptor agonists and risk of HCC.

Pubmed   Journal   ReadQx 

Letter to the editor: Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOTTM): A randomized, open-label, clinical trial.

Pubmed   Journal   ReadQx 

Provider preparedness for functional cure: Authors' reply.

Pubmed   Journal   ReadQx 

Reply: Is right heart assessment vital for evaluating terlipressin-related outcomes in Hepatorenal Syndrome-AKI ?

Pubmed   Journal   ReadQx 

Response to Letter to the Editor on portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOT).

Pubmed   Journal   ReadQx 

Serum matrix metalloproteinase-7 (MMP-7): As good as it gets?

Pubmed   Journal   ReadQx 

Solving the puzzle of fibrosis resolution in alcohol-associated liver disease: An insight from KDM5 demethylases and LXR activation.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Gastroenterology

Bridging the Diagnostic Gap: How Autonomous AI Can Assist in Endoscopic Diagnosis of Experts.

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Lessons from Japan's Case for Early Helicobacter pylori Screening.

Pubmed   Journal   ReadQx 

The optimal duration of vasoconstrictors for acute variceal hemorrhage: longer is safer?

Pubmed   Journal   ReadQx 

Gut

Response to: short-chain fatty acids in patients with severe acute pancreatitis: friend or foe?

Pubmed   Journal   ReadQx 

J Hepatol

Familial Coaggregation of MASLD and Liver-related Outcomes.

Pubmed   Journal   ReadQx 

The Transition from NAFLD to MASLD and Its Impact on Clinical Practice and Outcomes.

Pubmed   Journal   ReadQx